Interestingly enough, obstructive sleep apnea (OSA) has been considered a predominantly male disease. The truth is, more women have been diagnosed with OSA in recent years. The numbers do remain disproportionate, with 3-to-5x more men than women receiving OSA diagnoses.
Investigators from Brigham and Women’s Hospital and Yale School of Medicine set out to study the disparity and the causes. It was found that a high proportion of women experienced sleep apnea during dream sleep. This is associated with adverse outcomes including cardiovascular disease. The findings have implications for the screening, diagnosis, and treatment of OSA among women and men.
“Over the years, I’ve felt strongly that sleep apnea may be an exemplar of a chronic disease that may manifest differently in men and women, from how it presents to its underlying physiology, with implications for how it should be treated,” says senior author Susan Redline, MD, MPH, a senior physician in the Division of Sleep and Circadian Disorders in the Departments of Medicine and Neurology at the Brigham, in a release.
To conduct their study, the investigators analyzed participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Between 2010 and 2013, the team analyzed data from 2,057 MESA participants who underwent a comprehensive sleep study. The mean age of the study participants was 68.
What Did the Study Show
The team compared a range of summary measures of sleep apnea severity based on the apnea-hyponea index (AHI). An AHI greater than 15 is generally considered to indicate moderate to severe sleep apnea and is associated with increased risk of developing hypertension and mortality. The investigators calculated AHI numerous ways, some of which were more sensitive to capturing changes in breathing patterns during REM sleep and non-REM sleep. The team extracted detailed measures from the overnight sleep study to also estimate some of the mechanisms that may cause sleep apnea, including measures of the collapsibility of the airway, the sensitivity of breathing patterns to changes in oxygen, and changes in how quickly individuals woke up at night.
It was discovered that during non-REM sleep, twice as many men as women had an AHI score greater than 15. During REM sleep, however, the prevalence was the same in men and women. Among the study population, almost 60% of men and women met diagnostic criteria for moderately severe sleep apnea.
The study also found that the physiological mechanisms that influence sleep apnea differ in men and women.
“We are more and more appreciating that sleep apnea is a heterogeneous disease,” says corresponding author Christine Won, MD, MSc, the director of the Women’s Sleep Health program at Yale School of Medicine. “It’s important to understand how it affects men and women differently. Understanding sex-specific mechanisms allows us to target therapy and is expected to lead to better outcomes.”
Medical Requirements for Apnea
Medicare currently requires an oxygen desaturation level of 4% along with apnea events in order to consider someone to have OSA and receive coverage for treatment. The team found OSA rates that were almost double in women when these definitions that counted events that resulted in milder desaturation or awakenings compared to events that were only counted when larger amount of desaturation occurred.
“This suggests that women may be preferentially underdiagnosed when we use the Medicare definition of sleep apnea,” Redline says. “Women who have been evaluated using only home-based sleep studies should continue to speak to their doctor if they have not been diagnosed with sleep apnea but continue having symptoms.”
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